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KMID : 1130620070030010031
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Journal of Clinical Neurology
2007 Volume.3 No. 1 p.31 ~ p.37
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Comparison of Cognitive Effects of Lamotrigine and Oxcarbazepine in Epilepsy Patients
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Seo Jong-Geun
Lee Da-In
Hwang Yang-Ha
Lee Ho-Won
Jung Doo-Kyo
Suh Chung-Kyu
Kwon Soon-Hak
Park Sung-Pa
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Abstract
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Background and Purpose: This study compared the cognitive effects of 1 year of treatment with lamotrigine (LTG) and oxcarbazepine (OXC) in epilepsy patients.
Methods: This retrospective study investigated 60 epilepsy patients undergoing neuropsychological tests who were either newly diagnosed or untreated in the preceding 6 months. The cognitive function in 30 patients receiving LTG monotherapy and 30 age-matched patients receiving OXC monotherapy was compared after 1 year. The neuropsychological scores at baseline and all of the epilepsy-relevant variables except seizure type did not differ between the groups. The mean daily dosages of LTG and OXC at 1 year were 93 mg and 825 mg, respectively.
Results: The posttreatment list-learning performance was better in the LTG group than in the OXC group (p<0.05). The incidence of cognitive complaints did not differ between the two groups. The list-learning performance and Trail Making Test scores were better in each group after treatment.
Conclusions: LTG and OXC monotherapies have similar, slightly beneficial effects on cognitive function, and are probably not harmful
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KEYWORD
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Adverse effects, Cognition, Lamotrigine, Oxcarbazepine
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